Tecnológico de Costa Rica
  • ¿Cómo publicar en el Repositorio TEC?
  • Políticas
  • Recursos Educativos
  • Contáctenos
    • español
    • English
  • español 
    • español
    • English
  • Login
Ver ítem 
  •   Página Principal
  • Escuelas y Departamentos
  • Escuela de Biología
  • Artículos
  • Ver ítem
  •   Página Principal
  • Escuelas y Departamentos
  • Escuela de Biología
  • Artículos
  • Ver ítem
JavaScript is disabled for your browser. Some features of this site may not work without it.

Listar

Todo el RepositorioComunidades & ColeccionesPor fecha de publicaciónAutoresTítulosPalabras clavesTipo de Recurso EducativoDestinatarioEsta colecciónPor fecha de publicaciónAutoresTítulosPalabras clavesTipo de Recurso EducativoDestinatario

Mi cuenta

AccederRegistro

Estadísticas

Ver Estadísticas de uso

Towards autotrophic tissue engineering: photosynthetic gene therapy for regeneration

Thumbnail
Ver/
towards_autotrophic_tissue_engineering_photosynthetic.pdf (2.279Mb)
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946422630&doi=10.1016%2fj.biomaterials.2015.10.014&partnerID=40&md5=0fdffd34fcee87539470fbe452fe7774
Fecha
2016
Autor
Chávez, Myra Noemi
Ludwig-Schenck, Thilo
Hopfner, Ursula
Centeno-Cerdas, Carolina
Somlai-Schweiger, Ian
Schwarz, Christian
Machens, Hans-Günther
Heikenwalder, Mathias
Bono, María Rosa
Allende, Miguel
Nickelsen, Jörg
Egaña, José Tomás
Metadatos
Mostrar el registro completo del ítem
Resumen
The use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy to overcome this drawback, we have shown that photosynthetic biomaterials can produce and provide oxygen independently of blood perfusion by generating chimeric animal-plant tissues during dermal regeneration. In this work, we demonstrate the safety and efficacy of photosynthetic biomaterials in vivo after engraftment in a fully immunocompetent mouse skin defect model. Further, we show that it is also possible to genetically engineer such photosynthetic scaffolds to deliver other key molecules in addition to oxygen. As a proof-of-concept, biomaterials were loaded with gene modified microalgae expressing the angiogenic recombinant protein VEGF. Survival of the algae, growth factor delivery and regenerative potential were evaluated in vitro and in vivo. This work proposes the use of photosynthetic gene therapy in regenerative medicine and provides scientific evidence for the use of engineered microalgae as an alternative to deliver recombinant molecules for gene therapy.
Descripción
Artículo científico
Fuente
Biomaterials
URI
https://hdl.handle.net/2238/9849
DOI
10.1016/j.biomaterials.2015.10.014
Compartir
       
Métricas
Colecciones
  • Artículos [39]

|Contáctenos

Repositorio Institucional del Tecnológico de Costa Rica

Sistema de Bibliotecas del TEC | SIBITEC

© DERECHOS RESERVADOS. Un sitio soportado por DSpace(v. 6.3)

RT-1

 

 


|Contáctenos

Repositorio Institucional del Tecnológico de Costa Rica

Sistema de Bibliotecas del TEC | SIBITEC

© DERECHOS RESERVADOS. Un sitio soportado por DSpace(v. 6.3)

RT-1